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THE DR. OZ SHOW


14 OCT 2010
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09 NOV 2010
E! NEWS



 

Practical Dermatology "Investigating the Potential of Cryolipolysis in the Treatment of Fat"

In recent years, physicians have explored vast possibilities of treating fat in subtle ways via lasers and other devices. Among these is cryolipolysis, one of the most discussed and anticipated procedures in cosmetic dermatology. Unlike a laser, cryolipolysis works by cooling the skin, which in turn allows sculpts the body by eliminating fat in gradual and subtle ways, says one of the device’s creators, Dieter Manstein, MD. How does CoolSculpting by Zeltiq work? CoolSculpting is able to induce selective damage to the subcutaneous fatty tissue by controlled application of cold in a completely non-invasive manner, according to Dr. Manstein. "Under specific conditions, fat cells are most susceptible to cold injury and an apoptotic fat cell death is triggered. This means the fat cells are dying in a more gradual manner, resulting in marked fat loss over a period of approximately three months," he observes. First results are typically noticed after approximately three weeks.

 

Medesthetics Magazine "Freeze Away Fat"

The Zeltiq Cryolipolysis device has received United States Food & Drug Administration clearance for noninvasive fat layer reduction. Based on the science of Cryolipolysis—which shows that fat cells are naturally more sensitive to the effects of cold than surrounding skin cells—the system allows physicians to selectively target fat bulges using the CoolSculpting technique. "When we deliver precise cooling to discrete fat bulges on the body, the fatty lipids are slowly released and transported by the lymphatic system to be processed, much like fat from food," said Brian Zelickson, adjunct associate professor of dermatology, University of Minnesota Medical School. "CoolSculpting is an ideal choice for a wide range of patients who are reasonably fit and want spot reduction and shaping of fat bulges but are not considering a surgical or more invasive procedure."

 

Skin & Aging "Zeltiq Receives FDA Approval for Non-Invasive Fat Layer Reduction"

Zeltiq recently announced that it received clearance from FDA for non-invasive fat layer reduction located in the flank areas of the torso. According to a company-issued release, based on the science of cryolipolysis (cold lipolysis), CoolSculpting involves advanced cooling to gently and effectively reduce fat bulges in targeted areas of the body without needles, incisions, pain medication, or recovery time. The CoolSculpting procedure was developed at the Wellman Center for Photomedicine at Massachusetts General Hospital in Boston by Massachusetts General Hospital investigators and Harvard Medical School faculty Dr. Dieter Manstein and Dr. Rox Anderson. According to the company, the work of these investigators proved that fat cells are naturally more sensitive to the effects of cold than other cells, including surrounding skin cells. They were able to safely target and kill only the underlying fat, leaving surface skin tissue unaffected. "When we deliver precise cooling to discrete fat bulges on the body, the fatty lipids are slowly released and transported by the lymphatic system to be processed, much like fat from food," said Dr. Brian Zelickson, Adjunct Associate Professor, Dermatology, University of Minnesota Medical School, in the press release. "CoolSculpting is an ideal choice for a wide range of patients who are reasonably fit and want spot reduction and shaping of fat bulges, but are not considering a surgical or more invasive procedures." Beginning in 2007, clinical trials were conducted at 12 centers around the country, and patients participated in a non-randomized study with a prototype Zeltiq cooling device. Based on ultrasound assessment, an average fat layer reduction of 20% was demonstrated at 4 months after one procedure. No significant adverse events or patient discomfort were reported. CoolSculpting is already cleared by Health Canada and the European Union for non-invasive fat layer reduction. In the United States, the company says it is planning a controlled rollout of its Zeltiq system to core specialty physicians. The company announced that this rollout will be accompanied by educational support and technical training.

 

Skin & Allergy News "Cryolipolysis Offers Results for Fat Removal"

Cryolipolysis (CoolSculpting, Zeltiq Aesthetics) selectively kills fat cells at temperatures above freezing without affecting surrounding tissues. This selective crystallization of fat cells leads to cell destruction and, ultimately, gradual dissolution of fat over 2-4 months. Cryolipolysis is not a weight loss device, nor is it intended as a replacement for liposuction, said Dr. Avram, director of the Massachusetts General Hospital Dermatology Laser and Cosmetic Center. Cryolipolysis is best suited for local fat removal in areas resistant to diet and exercise, such as love handles, back fat, or the lower abdomen. Relatively thin, weight-stable people who have localized fat arees and realistic expectations are appropriate candidates.

 

Dermatology Times "FDA Ok’s Zeltiq Device for Treatment of Fatty Areas"

The Food and Drug Administration has cleared Zeltiq Aesthetics’ CoolSculpting, a cryosurgical device, for the noninvasive spot reduction of fat in diet-resistant areas such as "love handles," Medscape reports. According to a company statement, the device selectively targets subcutaneous fat cells with cold lipolysis, causing apoptosis and elimination to occur. Each one- to two-hour procedure yields a 20 percent reduction of fat in the treated area, with visible results within three weeks and the most dramatic results occurring over a two-to-four month period, the company states. The device was previously cleared in the European Union and other global markets. The company says the device is now available in select U.S. centers.





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